AMINO-1MQ (5-Amino-1MQ) – NNMT Inhibitor Research Compound
AMINO-1MQ (5-amino-1-methylquinolinium) is a small-molecule, membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular methylation and NAD+ metabolism. It is studied in metabolic research models for its effects on adipocyte energy expenditure and lipid metabolism.
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Research Applications
In laboratory research, AMINO-1MQ is investigated for NNMT enzyme inhibition and its downstream effects on NAD+ and S-adenosylmethionine (SAM) metabolism, adipocyte lipogenesis, and energy-expenditure pathways. Preclinical studies in diet-induced obese mice have examined its effects on adipose tissue and glucose tolerance. For more, see our AMINO-1MQ research guide.
- NNMT enzyme-inhibition studies
- NAD+ / SAM metabolic-cycle research
- Adipocyte lipogenesis and energy-expenditure models
Product Details
- Compound: AMINO-1MQ (5-amino-1-methylquinolinium)
- Purity: See Certificate of Analysis
- Form: Lyophilized powder
- Storage: Store at -20°C; after reconstitution, refrigerate at 2–8°C.
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Research References
- Mechanisms and inhibitors of nicotinamide N-methyltransferase. 2021. PMC
- Roles of nicotinamide N-methyltransferase in obesity and type 2 diabetes. Biomed Res Int. 2021;2021:9924314. Link
- Novel tricyclic small-molecule inhibitors of nicotinamide N-methyltransferase for the treatment of metabolic disorders. 2022. PMC
Nothing here is medical advice or a dosing recommendation.
Reconstitution Chart (2 mL)
Mixing reagent: Bacteriostatic water. Add 2 mL to the vial.
| Vial size | Concentration | Per 1 unit (100-unit syringe) | Per 10 units |
|---|---|---|---|
| 5 mg | 2.5 mg/mL | 25 mcg | 250 mcg |
| 10 mg | 5 mg/mL | 50 mcg | 500 mcg |
| 50 mg | 25 mg/mL | 250 mcg | 2500 mcg |
Chart shows mixing math only.
For research use only.
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